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«Winterthurerstr. 190 CH-8057 Zurich Year: 2009 Mechanisms of inflammation-induced hepatocarcinogenesis and prion transmission ...»

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University of Zurich

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Year: 2009

Mechanisms of inflammation-induced hepatocarcinogenesis and

prion transmission via the aerial route

Haybaeck, J

Haybaeck, J. Mechanisms of inflammation-induced hepatocarcinogenesis and prion transmission via the aerial

route. 2009, University of Zurich, Faculty of Science.

Postprint available at:


Posted at the Zurich Open Repository and Archive, University of Zurich.


Originally published at:

University of Zurich, Faculty of Science, 2009.

Mechanisms of Inflammation-induced Hepatocarcinogenesis and Prion Transmission via the Aerial Route Dissertation zur Erlangung der naturwissenschaftlichen Doktorwürde (Dr. sc. nat.) vorgelegt der Mathematisch-naturwissenschaftlichen Fakultät der Universität Zürich von Johannes Stephan Haybäck aus Österreich Promotionskomitee Prof. Dr. Adriano Aguzzi (Vorsitz und Leitung) Prof. Dr. Manfred Kopf Prof. Dr. Burkhard Becher Betreut durch Dr. Mathias Heikenwälder Zürich 2009 Die vorliegende Arbeit wurde von der mathematisch-naturwissenschaftlichen Fakultät der Universität Zürich auf Antrag von Professor Dr. Adriano Aguzzi als Dissertation angenommen.

Meiner Frau Cornelia To my wife Cornelia Table of contents Table of contents 4 SUMMARY: Mechanisms of Inflammation-induced Hepatocarcinogenesis 10 ZUSAMMENFASSUNG: Mechanismen der Entzündungs-induzierten Leberkarzinogenese 12



1.1 The most important signaling pathways involved in liver diseases 16 1.1.1 Overview about various signal transduction pathways 16 1.1.2 The VEGF signaling pathway 17 1.1.3 The Tumor Necrosis Factor signaling pathway 18 1.1.4 The NF-ĸB signaling pathway 19 1.1.5 The Interferon signaling pathway / JAK-STAT signaling pathway 22 1.1.6 The Wnt/-Catenin signaling pathway 23

1.2 The TNF superfamily with focus on Lymphotoxin 25 1.2.1 The TNF superfamily 25

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2.5.5 Intranasal prion inocualion is also extremely efficient in transmitting prion infectivity 124 Various mouse strains intranasally infected with prions succumb to scrapie 127

–  –  – Relevance of the complement system for prion pathogenesis after intranasal challenge 127 CCR7 or CXCR5 deficiency does not protect against intranasally administered prions 128 You are reading a preview. Would you like to access the full-text?

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Truncated prion protein and Doppel are myelinotoxic in the absence of oligodendrocytic PrPC. J Neurosci 25, 4879-4888.

Raeber, A.J., Klein, M.A., Frigg, R., Flechsig, E., Aguzzi, A., and Weissmann, C. (1999). PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice. EMBO J 18, 2702Rennert, P.D., Browning, J.L., Mebius, R., Mackay, F., and Hochman, P.S. (1996). Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs. J Exp Med 184, 1999Reuber, M., Al-Din, A.S., Baborie, A., and Chakrabarty, A. (2001). New variant Creutzfeldt-Jakob disease presenting with loss of taste and smell. J Neurol Neurosurg Psychiatry 71, 412-413.

Rieger, R., Edenhofer, F., Lasmezas, C.I., and Weiss, S. (1997). The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells. Nat Med 3, 1383-1388.

Riek, R., Hornemann, S., Wider, G., Billeter, M., Glockshuber, R., and Wüthrich, K. (1996). NMR structure of the mouse prion protein domain PrP(121-231). Nature 382, 180-182.

Riek, R., Hornemann, S., Wider, G., Glockshuber, R., and Wüthrich, K. (1997). NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231). FEBS Lett 413, 282-288.

Riek, R., Wider, G., Billeter, M., Hornemann, S., Glockshuber, R., and Wüthrich, K. (1998). Prion protein NMR structure and familial human spongiform encephalopathies. Proc Natl Acad Sci U S A 95, 11667-11672.

Riesner, D., Kellings, K., Wiese, U., Wulfert, M., Mirenda, C., and Prusiner, S.B. (1993). Prions and nucleic acids: search for "residual" nucleic acids and screening for mutations in the PrP-gene. Dev Biol Stand 80, 173Ringe, B., Wittekind, C., Weimann, A., Tusch, G., and Pichlmayr, R. (1992). Results of hepatic resection and transplantation for fibrolamellar carcinoma. Surg Gynecol Obstet 175, 299-305.

Rivera-Milla, E., Stuermer, C.A., and Malaga-Trillo, E. (2003). An evolutionary basis for scrapie disease:

identification of a fish prion mRNA. Trends Genet 19, 72-75.

Roberts, S.K., Ludwig, J., and Larusso, N.F. (1997). The pathobiology of biliary epithelia. Gastroenterology 112, 269-279.

Rollins, B.J., Morrison, E.D., and Stiles, C.D. (1988). Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. Proc Natl Acad Sci U S A 85, 3738-3742.

Ross, R.K., Yuan, J.M., Yu, M.C., Wogan, G.N., Qian, G.S., Tu, J.T., Groopman, J.D., Gao, Y.T., and Henderson, B.E. (1992). Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet 339, 943Rubel, L.R., Ishak, K.G., Benjamin, S.B., and Knuff, T.E. (1982). alpha 1-Antitrypsin deficiency and hepatocellular carcinoma. Association with cirrhosis, copper storage, and Mallory bodies. Arch Pathol Lab Med 106, 678-681.

Ruddell, R.G., Knight, B., Tirnitz-Parker, J.E., Akhurst, B., Summerville, L., Subramaniam, V.N., Olynyk, J.K., and Ramm, G.A. (2009). Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury. Hepatology 49, 227-239.

Ruddle, N.H., and Waksman, B.H. (1967). Cytotoxic effect of lymphocyte-antigen interaction in delayed hypersensitivity. Science 157, 1060-1062.

Russelakis-Carneiro, M., Betmouni, S., and Perry, V.H. (1999). Inflammatory response and retinal ganglion cell degeneration following intraocular injection of ME7 [In Process Citation]. Neuropathol Appl Neurobiol 25, 196-206.

Saborio, G.P., Soto, C., Kascsak, R.J., Levy, E., Kascsak, R., Harris, D.A., and Frangione, B. (1999). Celllysate conversion of prion protein into its protease-resistant isoform suggests the participation of a cellular chaperone. Biochem Biophys Res Commun 258, 470-475.

References Safar, J., Wille, H., Itri, V., Groth, D., Serban, H., Torchia, M., Cohen, F.E., and Prusiner, S.B. (1998). Eight prion strains have PrP(Sc) molecules with different conformations. Nat Med 4, 1157-1165.

Safar, J.G., Kellings, K., Serban, A., Groth, D., Cleaver, J.E., Prusiner, S.B., and Riesner, D. (2005). Search for a prion-specific nucleic acid. J Virol 79, 10796-10806.

Saito, H., Kanamori, Y., Takemori, T., Nariuchi, H., Kubota, E., Takahashi-Iwanaga, H., Iwanaga, T., and Ishikawa, H. (1998). Generation of intestinal T cells from progenitors residing in gut cryptopatches. Science 280, 275-278.

Sakamoto, M. (2009). Early HCC: diagnosis and molecular markers. J Gastroenterol 44 Suppl 19, 108-111.

Salman, M.D. (2003). Chronic wasting disease in deer and elk: scientific facts and findings. J Vet Med Sci 65, 761-768.

Santuccione, A., Sytnyk, V., Leshchyns'ka, I., and Schachner, M. (2005). Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth. J Cell Biol 169, 341-354.

Sawcer, S.J., Yuill, G.M., Esmonde, T.F., Estibeiro, P., Ironside, J.W., Bell, J.E., and Will, R.G. (1993).

Creutzfeldt-Jakob disease in an individual occupationally exposed to BSE. Lancet 341, 642.

Sbriccoli, M., Cardone, F., Valanzano, A., Lu, M., Graziano, S., De Pascalis, A., Ingrosso, L., Zanusso, G., Monaco, S., Bentivoglio, M., et al. (2009). Neuroinvasion of the 263K scrapie strain after intranasal administration occurs through olfactory-unrelated pathways. Acta Neuropathol 117, 175-184.

Schieferdecker, H.L., Schlaf, G., Jungermann, K., and Gotze, O. (2001). Functions of anaphylatoxin C5a in rat liver: direct and indirect actions on nonparenchymal and parenchymal cells. Int Immunopharmacol 1, 469-481.

Schlitt, H.J., Neipp, M., Weimann, A., Oldhafer, K.J., Schmoll, E., Boeker, K., Nashan, B., Kubicka, S., Maschek, H., Tusch, G., et al. (1999). Recurrence patterns of hepatocellular and fibrolamellar carcinoma after liver transplantation. J Clin Oncol 17, 324-331.

Schmitt-Ulms, G., Legname, G., Baldwin, M.A., Ball, H.L., Bradon, N., Bosque, P.J., Crossin, K.L., Edelman, G.M., DeArmond, S.J., Cohen, F.E., et al. (2001). Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. J Mol Biol 314, 1209-1225.

Schmitz, M.L., and Baeuerle, P.A. (1991). The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B. Embo J 10, 3805-3817.

Schnur, J., Olah, J., Szepesi, A., Nagy, P., and Thorgeirsson, S.S. (2004). Thioacetamide-induced hepatic fibrosis in transforming growth factor beta-1 transgenic mice. Eur J Gastroenterol Hepatol 16, 127-133.

Scott, J.R., Foster, J.D., and Fraser, H. (1993). Conjunctival instillation of scrapie in mice can produce disease.

Vet Microbiol 34, 305-309.

Seeger, H., Heikenwalder, M., Zeller, N., Kranich, J., Schwarz, P., Gaspert, A., Seifert, B., Miele, G., and Aguzzi, A. (2005). Coincident scrapie infection and nephritis lead to urinary prion excretion. Science 310, 324-326.

Seidel, B., Thomzig, A., Buschmann, A., Groschup, M.H., Peters, R., Beekes, M., and Terytze, K. (2007).

Scrapie Agent (Strain 263K) can transmit disease via the oral route after persistence in soil over years. PLoS ONE 2, e435.

Sekhon, S.S., Tan, X., Micsenyi, A., Bowen, W.C., and Monga, S.P. (2004). Fibroblast growth factor enriches the embryonic liver cultures for hepatic progenitors. Am J Pathol 164, 2229-2240.

Sell, S., Hunt, J.M., Dunsford, H.A., and Chisari, F.V. (1991). Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice. Cancer Res 51, 1278-1285.

Selzner, N., Selzner, M., Odermatt, B., Tian, Y., Van Rooijen, N., and Clavien, P.A. (2003). ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice. Gastroenterology 124, 692-700.

Sen, R., and Baltimore, D. (1986a). Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell 47, 921-928.

References Sen, R., and Baltimore, D. (1986b). Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46, 705-716.

Senftleben, U., Cao, Y., Xiao, G., Greten, F.R., Krahn, G., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S.C., et al. (2001). Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway.

Science 293, 1495-1499.

Shakhov, A.N., Lyakhov, I.G., Tumanov, A.V., Rubtsov, A.V., Drutskaya, L.N., Marino, M.W., and Nedospasov, S.A. (2000). Gene profiling approach in the analysis of lymphotoxin and TNF deficiencies. J Leukoc Biol 68, 151-157.

Shaw, I.C. (1995a). BSE and farmworkers. Lancet 346, 1365.

Shaw, I.C. (1995b). BSE and farmworkers [letter]. Lancet 346, 1365.

Shimoda, K., Mori, M., Shibuta, K., Banner, B.F., and Barnard, G.F. (1999). Vascular endothelial growth factor/vascular permeability factor mRNA expression in patients with chronic hepatitis C and hepatocellular carcinoma. Int J Oncol 14, 353-359.

Shmerling, D., Hegyi, I., Fischer, M., Blattler, T., Brandner, S., Gotz, J., Rulicke, T., Flechsig, E., Cozzio, A., von Mering, C., et al. (1998). Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell 93, 203-214.

Sigurdson, C.J., and Miller, M.W. (2003). Other animal prion diseases. Br Med Bull 66, 199-212.

Sigurdson, C.J., Williams, E.S., Miller, M.W., Spraker, T.R., O'Rourke, K.I., and Hoover, E.A. (1999). Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus). J Gen Virol 80, 2757-2764.

Simonetti, R.G., Camma, C., Fiorello, F., Politi, F., D'Amico, G., and Pagliaro, L. (1991). Hepatocellular carcinoma. A worldwide problem and the major risk factors. Dig Dis Sci 36, 962-972.

Simonic, T., Duga, S., Strumbo, B., Asselta, R., Ceciliani, F., and Ronchi, S. (2000). cDNA cloning of turtle prion protein. FEBS Lett 469, 33-38.

Siso, S., Gonzalez, L., Jeffrey, M., Martin, S., Chianini, F., and Steele, P. (2006a). Prion protein in kidneys of scrapie-infected sheep. Vet Rec 159, 327-328.

Siso, S., Hanzlicek, D., Fluehmann, G., Kathmann, I., Tomek, A., Papa, V., and Vandevelde, M. (2006b).

Neurodegenerative diseases in domestic animals: a comparative review. Vet J 171, 20-38.

Smith, P.E., Zeidler, M., Ironside, J.W., Estibeiro, P., and Moss, T.H. (1995). Creutzfeldt-Jakob disease in a dairy farmer. Lancet 346, 898.

Solforosi, L., Criado, J.R., McGavern, D.B., Wirz, S., Sanchez-Alavez, M., Sugama, S., DeGiorgio, L.A., Volpe, B.T., Wiseman, E., Abalos, G., et al. (2004). Cross-linking cellular prion protein triggers neuronal apoptosis in vivo. Science 303, 1514-1516.

Soto, C., and Castilla, J. (2004). The controversial protein-only hypothesis of prion propagation. Nat Med 10 Suppl, S63-67.

Spencer, M.D., Knight, R.S., and Will, R.G. (2002). First hundred cases of variant Creutzfeldt-Jakob disease:

retrospective case note review of early psychiatric and neurological features. BMJ (Clinical research ed 324, 1479-1482.

Spraker, T.R., O'Rourke, K.I., Balachandran, A., Zink, R.R., Cummings, B.A., Miller, M.W., and Powers, B.E. (2002a). Validation of monoclonal antibody F99/97.6.1 for immunohistochemical staining of brain and tonsil in mule deer (Odocoileus hemionus) with chronic wasting disease. J Vet Diagn Invest 14, 3-7.

Spraker, T.R., Zink, R.R., Cummings, B.A., Wild, M.A., Miller, M.W., and O'Rourke, K.I. (2002b).

Comparison of histological lesions and immunohistochemical staining of proteinase-resistant prion protein in a naturally occurring spongiform encephalopathy of free-ranging mule deer (Odocoileus hemionus) with those of chronic wasting disease of captive mule deer. Vet Pathol 39, 110-119.

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