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«Winterthurerstr. 190 CH-8057 Zurich Year: 2009 Mechanisms of inflammation-induced hepatocarcinogenesis and prion transmission ...»

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University of Zurich

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Year: 2009

Mechanisms of inflammation-induced hepatocarcinogenesis and

prion transmission via the aerial route

Haybaeck, J

Haybaeck, J. Mechanisms of inflammation-induced hepatocarcinogenesis and prion transmission via the aerial

route. 2009, University of Zurich, Faculty of Science.

Postprint available at:

http://www.zora.uzh.ch

Posted at the Zurich Open Repository and Archive, University of Zurich.

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Originally published at:

University of Zurich, Faculty of Science, 2009.

Mechanisms of Inflammation-induced Hepatocarcinogenesis and Prion Transmission via the Aerial Route Dissertation zur Erlangung der naturwissenschaftlichen Doktorwürde (Dr. sc. nat.) vorgelegt der Mathematisch-naturwissenschaftlichen Fakultät der Universität Zürich von Johannes Stephan Haybäck aus Österreich Promotionskomitee Prof. Dr. Adriano Aguzzi (Vorsitz und Leitung) Prof. Dr. Manfred Kopf Prof. Dr. Burkhard Becher Betreut durch Dr. Mathias Heikenwälder Zürich 2009 Die vorliegende Arbeit wurde von der mathematisch-naturwissenschaftlichen Fakultät der Universität Zürich auf Antrag von Professor Dr. Adriano Aguzzi als Dissertation angenommen.

Meiner Frau Cornelia To my wife Cornelia Table of contents Table of contents 4 SUMMARY: Mechanisms of Inflammation-induced Hepatocarcinogenesis 10 ZUSAMMENFASSUNG: Mechanismen der Entzündungs-induzierten Leberkarzinogenese 12

SELECTED DEFINITIONS 14

1. INTRODUCTION 16

1.1 The most important signaling pathways involved in liver diseases 16 1.1.1 Overview about various signal transduction pathways 16 1.1.2 The VEGF signaling pathway 17 1.1.3 The Tumor Necrosis Factor signaling pathway 18 1.1.4 The NF-ĸB signaling pathway 19 1.1.5 The Interferon signaling pathway / JAK-STAT signaling pathway 22 1.1.6 The Wnt/-Catenin signaling pathway 23

1.2 The TNF superfamily with focus on Lymphotoxin 25 1.2.1 The TNF superfamily 25

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2.5.5 Intranasal prion inocualion is also extremely efficient in transmitting prion infectivity 124 2.5.5.1 Various mouse strains intranasally infected with prions succumb to scrapie 127

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2.5.5.3 Relevance of the complement system for prion pathogenesis after intranasal challenge 127 2.5.5.4 CCR7 or CXCR5 deficiency does not protect against intranasally administered prions 128 You are reading a preview. Would you like to access the full-text?

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