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«Assoc. Prof. Zeynep Kalaylioglu Department of Statistics Middle East Technical University email: kzeynep Education: 1997-2002 Ph.D. in ...»

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Assoc. Prof. Zeynep Kalaylioglu

Department of Statistics

Middle East Technical University

email: kzeynep@metu.edu.tr

Education:

1997-2002 Ph.D. in Statistics, North Carolina State University, Raleigh-NC, USA

M.S. in Statistics (with minor in Computational Engineering

and Sciences),

North Carolina State University, Raleigh-NC, USA

1990-1995 B.S. in Statistics (concentration in Computer Architecture and

Programming), Middle East Technical University, Ankara, Turkey

Employment:

2007- Faculty, Department of Statistics, Middle East Technical University 2002-2007 Biostatistical researcher and programmer at Information Management Services for Division of Cancer Epidemiology and Genetics - National Cancer Institute, Bethesda-MD, USA 1995-1997 Research Assistant, Department of Statistics, METU

Publications:

Methodological “A novel approach for the analysis of clustered data with MAR observations,” with Recai Yucel (ongoing) “Modeling mixed clustered outcome with missing data,” with Alexandre de Leon (ongoing) “Bayesian model selection in MNAR models,” with Dimitris Karlis (ongoing) “A novel Bayesian approach for the analysis of response measured at a primary endpoint and longitudinal continuous covariate,” with Haydar Demirhan (submitted to Statistical Modelling) “Maximum likelihood estimation for multivariate log gamma distribution,” with Haydar Demirhan (to appear in Statistics and Probability Letters) Karagulle, S. and Kalaylioglu, Z.,“Score test for etiologic heterogeneity in two stage polytomous logistic regression,” (to appear in Journal of Applied Statistics) Demirhan, H. and Kalaylioglu, Z., (2015), “Joint prior distributions for variance parameters in normal hierarchical models,” J. of Multivariate Analysis, 135,163Kalaylioglu, Z. (2014), “Performances of Bayesian model selection criteria for generalised linear models with nonignorably missing covariates,” J. of Statistical Computation and Simulation, 84(8),1670-1691.

Kalaylioglu, Z., Bozdemir, B., Ghosh S. K. (2013), “Bayesian unit root test in stochastic volatility models with correlated errors,” Hacettepe J. of Mathematics and Statistics 42(6),659-669.

¨u Kalaylioglu, Z., Ozt¨rk, O. (2013), “Bayesian semiparametric models for nonignorable missing mechanisms in generalized linear models,” J. of Applied Statistics, 40(8),1746-1763.

Kalaylioglu, Z., Ghosh S. K., (2009), “Bayesian unit root tests for stochastic volatility models,” Statistical Methodology, 6(2), 189-201 Chatterjee, N., Kalaylioglu, Z., Shih J., Gail M., (2007),“Letter to the editor,” Biometrics, 63, 964-966.

Chatterjee, N., Kalaylioglu,Z., Moslehi, R., Peters, U., Wacholder, S., (2006), “Powerful multi-locus tests for genetic association in the presence of gene-gene and gene-environment interactions,” American Journal of Human Genetics, Vol. 79(6),1002Chatterjee, N., Kalaylioglu, Z., Shih J., Gail M., (2006),“Case-control and case-only designs with genotype and family history data: Estimating relative-risk, familial aggregation and absolute risk,” Biometrics, 62(1), 36-48.

Chatterjee, N., Kalaylioglu, Z., Carroll, R. J. (2005), “Exploiting gene-environment independence in family-based case-control studies: Increased power for detecting associations, interactions, and joint effects,” Genetic Epidemiology, 28, 138-156 Kalaylioglu, Z., Pantula, S. G. and Ghosh, S. K. (2002), “Frequentist and Bayesian unit root tests in stochastic volatility models,” unpublished Ph.D. thesis Applied Predicting complications at birth given blood sugar trend across the gestation weeks for pregnant diabetic women, with Seval Erdinc (submitted to Diabetes Research and Clinical Practice) Karatayli, S.C., Bozdayi, A.M., Karatayli, E., Ozturk, T., Husseini, A.A., Albayrak, R., Ozkan, M., Kalaylioglu, Z.. Yalcin, K., Cinar, K., Idilman, R., Yurdaydin, C. (2014), “Interleukin-28 gene polymorphisms may contribute to hbsag persistence and the development of hbeag-negative chronic hepatitis b,” Liver International, DOI: 10.1111/liv.12595.

Senses, K.M., Gonen, M., Barutcu, A.R., Kalaylioglu, Z., Isbilen, M., Konu, O., Chen, Y.T., Altorki, N.K., and Gure, A.O. (2013), “Cancer-testis gene expression is associated with the methylenetetrahydrofolate reductase 677 CT polymorphism in non-small cell lung carcinoma,” BMC Medical Genetics (http://www.biomedcentral.com/1471-2350/14/97).

Beklioglu, M., Bezirci, G., Akkas, S.B., Rinke, K., Yildirim, F., Kalaylioglu, Z.. Severcan, F. (2012), “Impacts of Salinity and Fish-Exuded Kairomone on the Survival and Macromolecular Profile of Daphnia Pulex,” Ecotoxicology, 21(2), 601Dogan, L., Kalaylioglu, Z., Karaman, N., Ozaslan, C., Atalay, C., Altinok, M. (2011)“Relationships Between Epidemiological Features and Tumor Characteristics of Breast Cancer,”Asian Pacific Journal of Cancer Prevention, 12(12), 3375-3380.

Vural, B., Demirkan, A., Ugurel, E., Kalaylioglu, Z., Esen, B.A., Gure, A.O., Gl, A., Ozbek, U. (2009), “Seroreactivity against PTEN-induced putative kinase 1 (PINK1) in Turkish patients with Beh¸ets disease,” Clinical and Experimental c Rheumatology, 27(2 Suppl 53):S67-72.

Saatci, E.,Kocak, Y., Akpinar, E., Kalaylioglu-Wheeler, Z. (2007), “Effect of chemotherapy on quality of life in patients with lymphoma,” Marmara Medical Journal, 20(2), 98-103 Sherman, M.E., Rimm, D.L., Yang, X., Chatterjee, N., Brinton, C., Lissowska, J., Peplonska, B. Szeszenia D., Mikolajczak, A.B., Zatonski, W., Cartun, R., Mandich, D., Rymkiewicz, G., Sikor, D.M, Lukaszek, S., Kordek, R., Kalaylioglu, Z., Harigopal, M., Charrette, L., Falk, R.T., Richesson, D., Anderson, W.F., Hewitt, S.M., Closas, M.G., (2007), “Variation in breast cancer hormone receptor and HER2 levels by etiologic factors: A population-based analysis,” International Journal of Cancer, September 1; 121(5): 1079-85 Garcia-Closas, M., Brinton, L. A., Chatterjee, N., Peplonska B., SzeszeniaDabrowska, N., Bardin-Mikolajczak, A., Zatonski, W., Blair, A., Anderson, W. F., Rymkiewicz, G., Mazepa-Sikora, D., Kordek, R., Lukaszek, S., Kalaylioglu, Z., Sherman, M. (2006), “Established breast cancer risk factors by clinically important tumor characteristics,” British Journal of Cancer, 95(1),123-129 Hisada, M., Chatterjee, N., Kalaylioglu, Z., Battjes, R. J., Goedert, J. J.





(2005), “Hepatitis C virus load and survival among injection drug users in the United States,” Hepatology, 42(6), 1446-1452

–  –  –

Talks presented:

• Oral Presentations Joint prior distributions for variance parameters in normal hierarchical models, Seventh International Workshop on Simulation, Rimini, Italy, May 2013.

Joint prior distributions for variance parameters in normal hierarchical models, Institut fur Mathematische Stokastik, Otto von Guericke Universitat, Magdeburg, Germany, October 2012.

Bayesian model selection criteria in generalized linear models with nonignorably missing covariates, Applied Statistics, Ribno, Slovenia, September 2012.

Bayesian model selection criteria in generalized linear models with nonignorably missing covariates, Uluslararasi Katilimli 14. Ulusal Biyoistatistik Kongresi, Kayseri, September 2012.

Bayesian semiparametric models for nonignorable missing mechanisms in generalized linear models, International Research Conference on Bayesian Learning, Yeditepe University, Istanbul, June 2011.

Bayesian semiparametric models for nonignorable missing mechanisms in generalized linear models, International Biometric Society, 6th. EMR Meeting, Hersonissos, Crete, May 2011.

Bayesian semiparametric models for nonignorable missing mechanisms in generalized linear models, Informatic Institute, Department of Health Informatics, METU, April 2011.

Bayesian semiparametric models for nonignorable missing mechanisms in generalized linear models, Department of Statistics, Ankara University, March 2011.

The role of statistics in genetic association studies: an overview and update, Workshop in Recent Developments in Applied Probability and Statistics, Institute of Applied Mathematics, METU, Ankara, March 2009.

Exploiting gene-environment independence in family-based case-control studies, Department of Statistics, METU, Ankara, February 2006.

Bayesian unit root tests in stochastic volatility models, American Statistical Association Meetings, New York City, NY, August 2002.

• Poster Presentations A joint prior for variance components in random effects models, 8th International Biometric Society-Eastern Mediterranean Region, Florence, Italy, July 2014.

A joint prior for variance components in random effects models, Bayesian Biostatistics, Zurich, Switzerland, July 2014.

Wind power forecast model, EAWE 9th. Ph.D. seminars in Wind Energy, Visby, Sweden, September 2013 (participated with the Ph.D. student).

Frequentist unit root tests in stochastic volatility models, American Statistical Association Meetings, San Fransisco, CA, August 2003.

Bayesian unit root tests in stochastic volatility models, NBER/NSF Time Series Workshop, Raleigh, NC, 2001.

• Lectures Statistical characterization of cultural heritage objects, International Atomic Energy Agency meetings, Saraykoy Nuclear Research and Training Center, Ankara, Markov chain Monte Carlo Methods - Gibbs Sampling, Department of Electrical and Electronical Engineering, METU, Ankara, 2010 Markov chain Monte Carlo methods for analysis of logistic regression via WinBUGS, Technische Universitat Dortmund, Germany, July 2009 Example of collaboration of health scientists and biostatisticians for a successful biomedical research: Hepatitis C virus infection and liver disease, Department of Statistics, METU, Ankara, 2008 Collaboration of health scientists and biostatisticians for a successful biomedical research: Two examples from NIH, Department of Biological Sciences, METU, Ankara, 2007 A two-stage logistic regression application: predictors of breast cancer risk by tumor size, grade, and nodal status, Graduate Summer School on New Advances in Statistics, Department of Statistics, METU, Ankara, 2007

Projects:

February, 2014 February 2014, METU Scientific Research Project: Bayesian modeling of mixed data with Gaussian copula in the presence of missing data (principle investigator) July 2009 - December 2011, EU FB-7, Short and long term effects of genetically modified organisms on animal health (researcher)

–  –  –

May 2009 - June 2010, Institute of Applied Mathematics METU, Construction of Turkish morbidity tables-incidence and prevelance estimation (researcher) February 20, 2009 February 2010-, METU Scientific Research Project (BAPBayesian unit root test for stochastic volatility models with leverage effect (principle investigator) Intramural Research Program of the National Cancer Institute USA (completed in 2007): Variation in breast cancer hormone receptor and HER2 levels by etiologic factors: A population-based analysis (data analyst) Intramural Research Program of the National Cancer Institute, Division of Cancer Epidemiology and Genetics, USA and FIS/Spain (00/0745, G03/174, G03/160, C03/09, C03/10) (completed in 2007): Large scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk (data analyst) Intramural Research Program of the National Cancer Institute, USA (completed in 2007): Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenoma (data analyst) Intramural Program of the National Institutes of Health, USA (completed in 2006): Powerful multi-locus tests for genetic association in the presence of gene-gene and gene-environment interactions (researcher) Intramural Research Program of the National Cancer Institute USA (completed in 2006): Established breast cancer risk factors by clinically important tumor characteristics (data analyst) Intramural Research Program of the National Cancer Institute, Division of Cancer Epidemiology and Genetics, USA and FIS/Spain (00/0745, G03/174, G03/160, C03/09, C03/10) (completed in 2006): Genetic Variation in the Nucleotide Excision Repair Pathway and Bladder Cancer Risk (data analyst) National Cancer Institute (CA-57030) and National Institute of Environmental Health Sciences (P30-ES09106), USA (completed in 2005): Exploiting geneenvironment independence in family-based case-control studies- Increased power for detecting associations, interactions, and joint effects (researcher) Intramural Research Program of the National Cancer Institute USA (completed in 2005): Hepatitis C virus load and survival among injection drug users in the United States (data analyst) National Cancer Institute (CA-90302, CA-57030) and National Institute of Environmental Health Sciences (P30-ES09306), USA (completed in 2005): Analysis of case-control studies of genetic and environmental factors with missing genetic information and haplotype-phase ambiguity (preliminary data analyst) National Cancer Institute and Texas A&M Center for Environmental and Rural Health, USA (completed in 2005): Semiparametric maximum likelihood estimation exploiting gene-environment independence in case-control studies (preliminary programmer)

Teaching:

• Courses Advanced Theory of Statistical Inference (Ph.D. compulsory) Biostatistics and Statistical Genetics (M.S. elective) Probability Theory (undergraduate compulsory) Computational Statistics (undergraduate compulsory) Biostatistics (undergraduate elective) Nonparametric Statistics (undergraduate compulsory) Categorical Data Analysis (undergraduate elective)

• Courses developed Applied Logistic Regression Analysis (graduate) Special Topics in Biostatistics (graduate) Biostatistics and Statistical Genetics (graduate)

Professional Activities:

• Statistical Consulting Wheat genotype analysis, Biochemistry, METU.

Effects of KML29 on fever induced by lipopolysaccharide, Biochemistry, METU:

A Bayesian mixed effects spline model Association between certain gene polymorphisms and risk of Hepatitis B infection, Institute of Hepatology-Ankara University Hospital.



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