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«9th International Biometals Symposium July 13-18, 2014 Duke University Durham, NC USA BioMetals 2014 Sponsors We are grateful for the generous ...»

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9th International

Biometals Symposium

July 13-18, 2014

Duke University

Durham, NC


BioMetals 2014 Sponsors

We are grateful for the generous support given by:

The Hanscom Endowment

through the Duke University

Office of Global Strategy and


Department of Chemistry

Funding for this conference was made possible (in part) by R13ES024653 from the National Institute of Environmental Health

Science. The view expressed in written conference materials of publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U. S. Government.

Research reported in the publication was supported by the National Institute Of Environmental Health Sciences of the National Institutes of Health under Award Number R13ES024653. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Dear Colleagues, It is with great pleasure that we welcome you to Duke University and the 9th International Biometals Symposium, BioMetals 2014. Our conference includes 170 international participants from over 25 countries on 5 continents. The conference format consists of 27 invited lectures, 34 contributed short talks, and over 120 posters. As always in the BioMetals conference series, our interdisciplinary theme is the exploration of metals in biology, medicine and the environment. BioMetals 2014 offers several subthemes: metal homeostasis in plants, metals at the host-pathogen interface, mechanisms for metal acquisition, metal cofactors, metal dependent signaling, metals in health and disease, environmental biology of trace metals, and metals in biotechnology.

During the course of the conference several awards will be given that will recognize outstanding graduate student and postdoctoral associate presentations including the Jorge Crosa awards. The International Biometals Society will also recognize the Heritage Award winner. The Igor Stojiljkovic Memorial Award will be presented to Shelley M. Payne, who will give the closing conference lecture.

We hope that you will take the opportunity on Monday evening and Wednesday afternoon and evening to explore the beautiful Duke University campus and the heart of Durham. The American Tobacco Campus, Brightleaf Square, Ninth Street, and the city center each offer a different atmosphere and interesting restaurants. We are highlighting an all-star baseball game and cookout on Wednesday, as well as other options, on and off campus, which will be suggested during the conference.

We thank the International Scientific Committee, Larry Barton, Pierre Cornelis, Manuel Lemos, Nigel Robinson, Isabelle Schalk, Hans Vogel, and Guenther Winkelmann, for their advice in designing the scientific program. We are grateful for the administrative assistance of Christiana Conti of the Duke Chemistry Department for her dedication and skill in synchronizing all aspects of this conference. We also thank our Duke volunteers for their assistance. We greatly appreciate financial assistance from our corporate and university sponsors, whose names are listed in the program. Most importantly, we thank you for your participation in making BioMetals 2014 a successful conference.

Best wishes, Al Crumbliss Kathy Franz Dennis Thiele Claire Siburt

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Page Welcome

Conference Maps

Technical Program and Schedule

Keynote Abstracts

Lecture Abstracts

Short Talk Abstracts

Poster Session A Abstracts

Poster Session B Abstracts

Poster Session C Abstracts

Author Index

Quick Reference Schedule

–  –  –

Sunday, July 13 3:00pm – 5:30pm Registration (Speakers Upload Talks) (Thomas Center Atrium) ____________________________________________________________________________

Welcome and Opening Keynote 5:30pm – 7:00pm Welcome Reception (Dinner Provided) (Thomas Center Atrium) 7:00pm – 8:30pm Opening Remarks and Keynote Lecture (Geneen Auditorium, Fuqua School of Business) K1: Sabeeha Merchant: Selective sub-cellular visualization of trace metals identifies dynamic sites of Cu accumulation in Chlamydomonas Monday, July 14 8:30am – 5:30 pm Refreshments (Kirby Reading Room, Fuqua School of Business) Group A Posters available (Kirby Reading Room) ____________________________________________________________________________

Metal Cofactors (Geneen Auditorium) Chair: Daniel Kosman

–  –  –

10:00am – 10:15am ST3: Artur Krezel: Interplay between zinc coordination architecture and stability of zinc proteins – insights into zinc protein regulation 10:15am – 10:45am Break/Refreshments (Kirby Reading Room) ____________________________________________________________________________

Environmental Biology of Trace Metals (Geneen Auditorium) Chair: Andrew Ghio 10:45am – 11:15am L3: Mak Saito: Connecting metal scarcity to metalloenzymes in the oceans - building a global ocean metabolism diagnostic capability using proteomics 11:15am – 11:30am ST4: Anne Summers: Differential proteomic and physiological consequences for E. coli of organic or inorganic mercury exposure 11:30am – 11:45am ST5: William Sunda: High growth requirement for cellular iron in a coastal Synechococcus species: evolutionary and ecological implications 11:45am – 12:00pm ST6: Owen Duckworth: The geobiology of manganese oxide formation in an environmental remediation system ____________________________________________________________________________

12:00pm – 1:30pm Lunch Provided (Winter Garden, Fuqua School of Business) Group A Posters available (Kirby Reading Room) Metals at the Host Pathogen Interface (Geneen Auditorium) Chair: Dietrich Nies

–  –  –

ST12: Philippe Delepelaire: Structural basis for heme acquisition from 5:15pm – 5:30pm hemopexin by HxuA from Haemophilus influenzae ____________________________________________________________________________

Poster Session A (Kirby Reading Room) 5:30pm – 7:30pm Poster Session A with cash bar Note: Dinner available at participant’s expense (Thomas Center, 7:30-9:30pm; see registration packet for other dinner venues on campus and nearby restaurants).

Note: Group A Posters available in Kirby Reading Room until 10:00pm.

Tuesday, July 15 8:30am – 5:00 pm Refreshments (Kirby Reading Room) Group B Posters available (Kirby Reading Room) ____________________________________________________________________________

Metal Homeostasis in Plants (Geneen Auditorium) Chair: Elena Fabiano

–  –  –

9:45am – 10:15am Break/Refreshments (Kirby Reading Room) 10:15am – 10:45am L10: Antonella Furini: Molecular tools to unravel the mechanisms of metal accumulation in plants 10:45am – 11:00am ST14: Gerhard Geipel: Uranium redox processes and uptake by plant cells 11:00am – 11:15am Break/Refreshments (Kirby Reading Room) ____________________________________________________________________________

Metals in Health and Disease (Geneen Auditorium) Chair: R. Martin Roop 11:15am – 11:45am L11: Jonathan Gitlin: The inherited disorders of copper homeostasis 11:45am – 12:00pm ST15: Christoph Fahrni: Illuminating the redistribution dynamics of transition metals during cell proliferation and embryonic development ____________________________________________________________________________

–  –  –

ST18: Tom Bartnikas: Perturbations in metal homeostasis in transferrinpm – 4:45pm deficient mice are metal-specific and partially reversible ____________________________________________________________________________

Poster Session B (Kirby Reading Room) 4:45pm – 6:45pm Poster Session B with cash bar ____________________________________________________________________________

Dinner and Evening Keynote (French Family Science Center) 6:45pm – 8:30pm Dinner Provided by the Duke Chemistry Department (FFSC Atrium)

–  –  –

Note: Group B Posters available in Kirby Reading Room until 10:00pm.

Wednesday, July 16 8:30am – 12:30 pm Refreshments (Kirby Reading Room) Group C Posters available (Kirby Reading Room) ____________________________________________________________________________

Metal Dependent Signaling (Geneen Auditorium) Chair: Simon Andrews

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10:00am – 10:15am ST21: Andrew Foster: Metal-specificity of cyanobacterial nickelresponsive repressor InrS: cells maintain zinc and copper below the detection-threshold for InrS 10:15am – 10:45am Break/Refreshments (Kirby Reading Room)

–  –  –

11:45am – 12:00pm ST22: Iain Lamont: Cryptic siderophore synthesis in the plant pathogen Pseudomonas syringae pv actinidae 12:00pm – 12:15pm ST23: Amanda Bird: Molecular control of zinc ion distribution in eukaryotes 12:15pm – 12:30pm ST24: Sangwom Kim: Lysosomal iron modulates synaptic excitability via Dexras1/DMT1 pathway in neurons ____________________________________________________________________________

–  –  –

Poster Session C (Kirby Reading Room) 1:30pm – 3:30pm Poster Session C with refreshments ____________________________________________________________________________

–  –  –

Note: Optional activities and shuttles to downtown Durham will be provided.

Note: Group C Posters available in Kirby Reading Room until 10:00pm.

Thursday, July 17 8:30am – 5:30 pm Refreshments (Kirby Reading Room) Group C Posters available (Kirby Reading Room) ____________________________________________________________________________

Metals in Biotechnology (Geneen Auditorium) Chair: Daniela Buccella

–  –  –

10:00am – 10:30am Break/Refreshments (Kirby Reading Room) 10:30am – 11:00am L22: Giselle Cerchiaro: Copper, Iron & Zinc: chemical quantification in biological samples 11:00am – 11:15am ST27: Nicole Bouley Ford: Determination of biomolecular interactions using MicroScale Thermophoresis ____________________________________________________________________________

Mechanisms for Metal Acquisition (Geneen Auditorium) Chair: Ute Moellmann 11:15am – 11:45am L23: Alison Butler: Biosynthesis and chemical biology of acylated siderophores 11:45am – 12:00pm ST28: Rachel Codd: Approaches in chemical biology for the discovery of new native and engineered siderophores and receptors ____________________________________________________________________________

–  –  –

4:00pm – 4:30pm Break/Refreshments (Kirby Reading Room) ____________________________________________________________________________

Awards and Closing Lecture (Geneen Auditorium) 4:30pm – 5:00pm Awards Ceremony

–  –  –

Selective sub-cellular visualization of trace metals identifies dynamic sites of Cu accumulation in Chlamydomonas Sabeeha S. Merchant1,2, Anne Hong-Hermesdorf1, Marcus Miethke1, Sean D. Gallaher1, Janette Kropat1, Sheel C. Dodani4, Dulmini Barupala5, Jefferson Chan4, Dylan Domaille4, Dyna Shirasaki3, Joseph A. Loo1,2,3, Jennifer Pett-Ridge6, Timothy L.

Stemmler5, Christopher J. Chang4 Department of Chemistry and Biochemistry, University of California, Los Angeles, USA.

Institute for Genomics and Proteomics, University of California, Los Angeles, USA.

Department of Biological Chemistry, University of California, Los Angeles, USA.

Department of Chemistry and Howard Hughes Medical Institute, University of California, Berkeley, USA.

Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, USA.

Lawrence Livermore National Laboratory, Livermore, USA.

During zinc limitation, Chlamydomonas hyperaccumulates copper in a pathway dependent on the nutritional copper sensor Crr1. Nevertheless, the cells are functionally copper-deficient, suggestive of copper compartmentalization. Visualization of intracellular Cu(I) reveals distinct foci of Cu(I) accumulation, similar in size to electrondense structures and coincident with lysosome and polyphosphate staining, suggesting that they are lysosome-derived compartments. Both NanoSIMS and fluorescent staining show colocalization of Ca and Cu to these sites, named cuprosomes. X-ray absorption spectroscopy (XAS) of Cu(I)-accumulating cells is consistent with Cu(I) organized in an ordered structure with N, O and S ligands. Zinc resupply restores copper homeostasis and is concomitant with reduced abundance of cuprosomes. Isotope labeling experiments demonstrate that the previously-sequestered Cu(I) becomes bioavailable for the synthesis of cuproproteins like plastocyanin, and transcriptome profiling indicates that mobilized Cu(I) becomes visible to Crr1. Copper-trafficking to cuprosomes may be a strategy for both preventing protein mis-metallation during zinc deficiency and efficient cuproprotein (re)-metallation upon zinc resupply.

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